MRS3/YJL133W Summary Help

Standard Name MRS3 1, 2
Systematic Name YJL133W
Feature Type ORF, Verified
Description Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication (3, 4, 5, 6)
Name Description Mitochondrial RNA Splicing 7
Chromosomal Location
ChrX:160619 to 161563 | ORF Map | GBrowse
Gene Ontology Annotations All MRS3 GO evidence and references
  View Computational GO annotations for MRS3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Classical genetics
Large-scale survey
34 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • PCA: 2

Genetic Interactions
  • Dosage Lethality: 3
  • Dosage Rescue: 9
  • Negative Genetic: 5
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 3
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 3

Expression Summary
Length (a.a.) 314
Molecular Weight (Da) 34,501
Isoelectric Point (pI) 8.34
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrX:160619 to 161563 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..945 160619..161563 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000003669
References cited on this page View Complete Literature Guide for MRS3
1) Schmidt C, et al.  (1987) Nuclear suppression of a mitochondrial RNA splice defect: nucleotide sequence and disruption of the MRS3 gene. Mol Gen Genet 210(1):145-52
2) Sollner T, et al.  (1987) Amplification of the yeast nuclear gene MRS3 confers suppression of a mitochondrial RNA splice defect. Curr Genet 12(7):497-501
3) Wiesenberger G, et al.  (1991) MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family. J Mol Biol 217(1):23-37
4) Muhlenhoff U, et al.  (2003) A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions. J Biol Chem 278(42):40612-20
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Froschauer EM, et al.  (2009) The yeast mitochondrial carrier proteins Mrs3p/Mrs4p mediate iron transport across the inner mitochondrial membrane. Biochim Biophys Acta 1788(5):1044-50
7) Kreike J, et al.  (1986) Cloning of a nuclear gene MRS1 involved in the excision of a single group I intron (bI3) from the mitochondrial COB transcript in S. cerevisiae. Curr Genet 11(3):185-91