MRS1/YIR021W Summary Help

Standard Name MRS1 1
Systematic Name YIR021W
Alias PET157
Feature Type ORF, Verified
Description Splicing protein; required for splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA; MRS1 has a paralog, CCE1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Mitochondrial RNA Splicing 1
Chromosomal Location
ChrIX:397294 to 398385 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MRS1 GO evidence and references
  View Computational GO annotations for MRS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
23 total interaction(s) for 19 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Protein-RNA: 2
  • Reconstituted Complex: 2

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 8
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 363
Molecular Weight (Da) 41,289
Isoelectric Point (pI) 8.83
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:397294 to 398385 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1092 397294..398385 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001460
References cited on this page View Complete Literature Guide for MRS1
1) Kreike J, et al.  (1986) Cloning of a nuclear gene MRS1 involved in the excision of a single group I intron (bI3) from the mitochondrial COB transcript in S. cerevisiae. Curr Genet 11(3):185-91
2) Bousquet I, et al.  (1990) Two group I mitochondrial introns in the cob-box and coxI genes require the same MRS1/PET157 nuclear gene product for splicing. Curr Genet 18(2):117-24
3) Bassi GS, et al.  (2002) Recruitment of intron-encoded and co-opted proteins in splicing of the bI3 group I intron RNA. Proc Natl Acad Sci U S A 99(1):128-33
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61