MRPL3/YMR024W Summary Help

Standard Name MRPL3 1
Systematic Name YMR024W
Feature Type ORF, Verified
Description Mitochondrial ribosomal protein of the large subunit; located in close proximity to the polypeptide exit channel of the ribosome; mutations in human homolog MRPL44 cause childhood cardiomyopathy; human MRPL44 deficiency results in inefficient assembly of the mitochondrial ribosome, and in tissue-specific respiratory chain deficiency, manifesting as either Complex I+Complex IV or Complex IV deficiency, depending on a cell type (2, 3)
Name Description Mitochondrial Ribosomal Protein, Large subunit
Gene Product Alias YmL3 4
Chromosomal Location
ChrXIII:321875 to 323047 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MRPL3 GO evidence and references
  View Computational GO annotations for MRPL3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Large-scale survey
null
overexpression
Resources
62 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 52
  • Affinity Capture-RNA: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 2
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 390
Molecular Weight (Da) 43,999
Isoelectric Point (pI) 10.24
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:321875 to 323047 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1173 321875..323047 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004626
References cited on this page View Complete Literature Guide for MRPL3
1) Kitakawa M, et al.  (1997) Identification and characterization of the genes for mitochondrial ribosomal proteins of Saccharomyces cerevisiae. Eur J Biochem 245(2):449-56
2) Graack HR and Wittmann-Liebold B  (1998) Mitochondrial ribosomal proteins (MRPs) of yeast. Biochem J 329 ( Pt 3)():433-48
3) Carroll CJ, et al.  (2013) Whole-exome sequencing identifies a mutation in the mitochondrial ribosome protein MRPL44 to underlie mitochondrial infantile cardiomyopathy. J Med Genet 50(3):151-9
4) Graack HR, et al.  (1988) Mitochondrial ribosomes of yeast: isolation of individual proteins and N-terminal sequencing. FEBS Lett 242(1):4-8