MRL1/YPR079W Summary Help

Standard Name MRL1 1
Systematic Name YPR079W
Feature Type ORF, Verified
Description Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress (1, 2)
Name Description Mannose 6-phosphate Receptor Like 1
Chromosomal Location
ChrXVI:698869 to 700014 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MRL1 GO evidence and references
  View Computational GO annotations for MRL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Large-scale survey
null
overexpression
unspecified
Resources
65 total interaction(s) for 54 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • PCA: 15

Genetic Interactions
  • Negative Genetic: 38
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 381
Molecular Weight (Da) 42,706
Isoelectric Point (pI) 8.75
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:698869 to 700014 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1146 698869..700014 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006283
References cited on this page View Complete Literature Guide for MRL1
1) Whyte JR and Munro S  (2001) A yeast homolog of the mammalian mannose 6-phosphate receptors contributes to the sorting of vacuolar hydrolases. Curr Biol 11(13):1074-8
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76