MPT5/YGL178W Summary 
| Standard Name | MPT5 1 |
|---|---|
| Systematic Name | YGL178W |
| Alias | HTR1 , PUF5 , UTH4 |
| Feature Type | ORF, Verified |
| Description | mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity (1, 2, 3, 4, 5, 6, 7, 8, 9) |
| Name Description | Multicopy suppressor of Pop Two 10 |
| Chromosomal Location | |
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Gene Ontology Annotations All MPT5 GO evidence and references
| View Computational GO annotations for MPT5 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated | |
| High-throughput |
Mutant phenotypes All MPT5 Phenotype evidence and references
| Classical genetics | |
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| null |
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| unspecified | |
| Resources |
interactions All MPT5 Interaction evidence and references
| 72 total interaction(s) for 41 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All MPT5 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
| This feature contains embedded feature(s): YGL177W | |||||||||||||||||||||||
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||||||||||||
| Subfeature details |
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Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000003146 |
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References cited on this page View Complete Literature Guide for MPT5
| 1) | Chen T and Kurjan J (1997) Saccharomyces cerevisiae Mpt5p interacts with Sst2p and plays roles in pheromone sensitivity and recovery from pheromone arrest. Mol Cell Biol 17(6):3429-39 |
| 2) | Kennedy BK, et al. (1997) Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89(3):381-91 |
| 3) | Tadauchi T, et al. (2001) Post-transcriptional regulation through the HO 3'-UTR by Mpt5, a yeast homolog of Pumilio and FBF. EMBO J 20(3):552-61 |
| 4) | Kaeberlein M and Guarente L (2002) Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160(1):83-95 |
| 5) | Gerber AP, et al. (2004) Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. PLoS Biol 2(3):E79 |
| 6) | Goldstrohm AC, et al. (2006) PUF proteins bind Pop2p to regulate messenger RNAs. Nat Struct Mol Biol 13(6):533-9 |
| 7) | Stewart MS, et al. (2007) Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway. Eukaryot Cell 6(2):262-70 |
| 8) | Traven A, et al. (2010) The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress. PLoS One 5(5):e10651 |
| 9) | Cridge AG, et al. (2010) Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins. Nucleic Acids Res 38(22):8039-50 |
| 10) | Hata H, et al. (1998) Dhh1p, a putative RNA helicase, associates with the general transcription factors Pop2p and Ccr4p from Saccharomyces cerevisiae. Genetics 148(2):571-9 |
