STM1/YLR150W Summary Help

STM1 BASIC INFORMATION

Standard Name STM1 1
Systematic Name YLR150W
Alias MPT4 2
Feature Type ORF, Verified
Description Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure (1, 3, 4, 5, 6, 7)
Name Description Suppressor of tom1 1
GO Annotations All STM1 GO evidence and references
    View Computational GO annotations for STM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All STM1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
overexpression
Interactions STM1 All interactions details and references
157 total interaction(s) for 145 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 124
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 5
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 4
  • Dosage Rescue: 13
  • Synthetic Lethality: 5
  • Synthetic Rescue: 2
Sequence Information
ChrXII:440468 to 441289 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..822 440468..441289 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004140

STM1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Localization Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for STM1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
TIF3Nomenclature conflictBoth YPR163C/TIF3 and YLR150W/STM1 have been referred to as STM1.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for STM1]

1) Utsugi T, et al.  (1995) A high dose of the STM1 gene suppresses the temperature sensitivity of the tom1 and htr1 mutants in Saccharomyces cerevisiae. Biochim Biophys Acta 1263(3):285-8
2) Frantz JD and Gilbert W  (1995) A yeast gene product, G4p2, with a specific affinity for quadruplex nucleic acids. J Biol Chem 270(16):9413-9
3) Nelson LD, et al.  (2000) The yeast STM1 gene encodes a purine motif triple helical DNA-binding protein. J Biol Chem 275(8):5573-81
4) Hayashi N and Murakami S  (2002) STM1, a gene which encodes a guanine quadruplex binding protein, interacts with CDC13 in Saccharomyces cerevisiae. Mol Genet Genomics 267(6):806-13
5) Van Dyke MW, et al.  (2004) Stm1p, a G4 quadruplex and purine motif triplex nucleic acid-binding protein, interacts with ribosomes and subtelomeric Y' DNA in Saccharomyces cerevisiae. J Biol Chem 279(23):24323-33
6) Van Dyke N, et al.  (2006) Stm1p, a ribosome-associated protein, is important for protein synthesis in Saccharomyces cerevisiae under nutritional stress conditions. J Mol Biol 358(4):1023-31
7) Van Dyke N, et al.  (2009) Stm1p alters the ribosome association of eukaryotic elongation factor 3 and affects translation elongation. Nucleic Acids Res 37(18):6116-25