MPS3/YJL019W Summary Help

Standard Name MPS3 1
Systematic Name YJL019W
Alias NEP98 2 , YJL018W
Feature Type ORF, Verified
Description Nuclear envelope protein; required for SPB insertion, initiation of SPB duplication and nuclear fusion; interacts with Mps2p to tether half-bridge to core SPB; N-terminal acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; member of the SUN protein family (Sad1-UNC-84 homology) (1, 2, 3, 4, 5, 6, 7)
Name Description MonoPolar Spindle 1
Chromosomal Location
ChrX:402897 to 404945 | ORF Map | GBrowse
Gene Ontology Annotations All MPS3 GO evidence and references
  View Computational GO annotations for MPS3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 95 genes
Classical genetics
reduction of function
Large-scale survey
229 total interaction(s) for 174 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 9
  • Biochemical Activity: 1
  • Co-localization: 3
  • Far Western: 1
  • Protein-RNA: 1
  • Reconstituted Complex: 11
  • Two-hybrid: 58

Genetic Interactions
  • Dosage Rescue: 6
  • Negative Genetic: 2
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 3
  • Positive Genetic: 3
  • Synthetic Growth Defect: 60
  • Synthetic Lethality: 19
  • Synthetic Rescue: 44

Expression Summary
Length (a.a.) 682
Molecular Weight (Da) 79,174
Isoelectric Point (pI) 5
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrX:402897 to 404945 | ORF Map | GBrowse
This feature contains embedded feature(s): YJL018W
Last Update Coordinates: 2011-02-03 | Sequence: 2003-01-02
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2049 402897..404945 2011-02-03 2003-01-02
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003556
References cited on this page View Complete Literature Guide for MPS3
1) Jaspersen SL, et al.  (2002) Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p. J Cell Biol 159(6):945-56
2) Nishikawa S, et al.  (2003) Nep98p is a component of the yeast spindle pole body and essential for nuclear division and fusion. J Biol Chem 278(11):9938-43
3) Jaspersen SL, et al.  (2006) The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope. J Cell Biol 174(5):665-75
4) Conrad MN, et al.  (2008) Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination. Cell 133(7):1175-87
5) Friederichs JM, et al.  (2011) The SUN Protein Mps3 Is Required for Spindle Pole Body Insertion into the Nuclear Membrane and Nuclear Envelope Homeostasis. PLoS Genet 7(11):e1002365
6) Ghosh S, et al.  (2012) Acetylation of the SUN protein Mps3 by Eco1 regulates its function in nuclear organization. Mol Biol Cell 23(13):2546-59
7) Friederichs JM, et al.  (2012) Genetic Analysis of Mps3 SUN Domain Mutants in Saccharomyces cerevisiae Reveals an Interaction with the SUN-Like Protein Slp1. G3 (Bethesda) 2(12):1703-18