Standard Name	MPS3 1
Systematic Name	YJL019W
Alias	NEP98 2 , YJL018W
Feature Type	ORF, Verified
Description	Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p (1, 2, 3, 4, 5, 6)
Name Description	MonoPolar Spindle 1

Chromosomal Location	ChrX:402897 to 404945 | ORF Map | GBrowse

	View Computational GO annotations for MPS3
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chromatin silencing at telomere (IMP) establishment of mitotic sister chromatid cohesion (IMP) meiotic telomere clustering (IGI, IMP) mitotic sister chromatid cohesion (IMP) nuclear migration involved in conjugation with cellular fusion (IMP) spindle pole body duplication associated with nuclear envelope (IMP) synapsis (IGI, IMP) telomere tethering at nuclear periphery (IMP)
Cellular Component
Manually curated	half bridge of spindle pole body (IDA) integral to membrane (IDA) nuclear chromosome, telomeric region (IDA) nuclear envelope (IDA) nuclear periphery (IDA)

Classical genetics
conditional	cell cycle progression in M phase: arrested heat sensitivity: increased sporulation: absent
reduction of function	GFP-Rap1 distribution: abnormal
unspecified	inviable
Large-scale survey
conditional	resistance to hydroxyurea: decreased resistance to benomyl: decreased
null	inviable oxidative stress resistance: decreased starvation resistance: decreased
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	225 total interaction(s) for 172 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Affinity Capture-Western: 9 Biochemical Activity: 1 Co-localization: 3 Far Western: 1 Protein-RNA: 1 Reconstituted Complex: 11 Two-hybrid: 57
Genetic Interactions	Dosage Rescue: 5 Negative Genetic: 2 Phenotypic Enhancement: 2 Phenotypic Suppression: 3 Positive Genetic: 3 Synthetic Growth Defect: 60 Synthetic Lethality: 19 Synthetic Rescue: 44
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:402897 to 404945 | ORF Map | GBrowse
	This feature contains embedded feature(s): YJL018W
Last Update	Coordinates: 2011-02-03 | Sequence: 2003-01-02
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2049 402897..404945 2011-02-03 2003-01-02
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003556