MPS2/YGL075C Summary Help

Standard Name MPS2 1
Systematic Name YGL075C
Alias MMC1
Feature Type ORF, Verified
Description Essential membrane protein localized at nuclear envelope and SPBs; required for insertion of the newly duplicated spindle pole body into the nuclear envelope; potentially phosphorylated by Cdc28p; MPS2 has a paralog, CSM4, that arose from the whole genome duplication (2, 3, 4)
Name Description MonoPolar Spindle 1, 2
Chromosomal Location
ChrVII:368088 to 366925 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MPS2 GO evidence and references
  View Computational GO annotations for MPS2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 8 genes
Resources
Classical genetics
overexpression
unspecified
Large-scale survey
conditional
null
overexpression
reduction of function
repressible
Resources
105 total interaction(s) for 67 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-Western: 5
  • Biochemical Activity: 5
  • Co-localization: 1
  • Co-purification: 2
  • FRET: 3
  • PCA: 1
  • Reconstituted Complex: 5
  • Two-hybrid: 50

Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 7
  • Phenotypic Suppression: 2
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 10
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 387
Molecular Weight (Da) 44,585
Isoelectric Point (pI) 8.58
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:368088 to 366925 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1164 368088..366925 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003043
References cited on this page View Complete Literature Guide for MPS2
1) Winey M, et al.  (1991) MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication. J Cell Biol 114(4):745-54
2) Munoz-Centeno MC, et al.  (1999) Saccharomyces cerevisiae MPS2 encodes a membrane protein localized at the spindle pole body and the nuclear envelope. Mol Biol Cell 10(7):2393-406
3) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61