MPC2/YHR162W Summary Help

Standard Name MPC2 1, 2
Systematic Name YHR162W
Feature Type ORF, Verified
Description Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; MPC2 has a paralog, FMP43, that arose from the whole genome duplication (1, 2, 3)
Name Description Mitochondrial Pyruvate Carrier 1, 2
Chromosomal Location
ChrVIII:423072 to 423461 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MPC2 GO evidence and references
  View Computational GO annotations for MPC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 20 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
31 total interaction(s) for 26 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 4

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 2
  • Negative Genetic: 8
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 129
Molecular Weight (Da) 14,555
Isoelectric Point (pI) 11.13
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:423072 to 423461 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..390 423072..423461 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001205
References cited on this page View Complete Literature Guide for MPC2
1) Bricker DK, et al.  (2012) A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science 337(6090):96-100
2) Herzig S, et al.  (2012) Identification and functional expression of the mitochondrial pyruvate carrier. Science 337(6090):93-6
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61