Standard Name	MON2
Systematic Name	YNL297C
Alias	YSL2
Feature Type	ORF, Verified
Description	Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins (1)
Name Description	MONensin sensitivity 2

Chromosomal Location	ChrXIV:76583 to 71673 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for MON2
Molecular Function
Manually curated	guanyl-nucleotide exchange factor activity (IGI, IPI, ISS)
Biological Process
Manually curated	endocytosis (IMP) Golgi to endosome transport (IMP) transport (IMP, ISS)
High-throughput	protein targeting to vacuole (IMP)
Cellular Component
Manually curated	cytosol (TAS) endosome (IDA) extrinsic to membrane (IDA) trans-Golgi network (IDA)

Classical genetics
null	tellurium atom accumulation: decreased lithium(1+) accumulation: decreased metal resistance: decreased GFP-Dop1p distribution: abnormal GFP-Snc1p distribution: abnormal GFP-Snc1p modification: decreased resistance to monensin: decreased resistance to brefeldin A: decreased
Large-scale survey
null	rubidium(1+) accumulation: decreased glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased filamentous growth: increased haploinsufficient heat sensitivity: increased hyperosmotic stress resistance: decreased ionic stress resistance: decreased resistance to fenpropimorph: increased resistance to sirolimus: decreased resistance to wortmannin: decreased resistance to ethanol: decreased resistance to (S)-lactic acid: decreased resistance to sodium arsenite: decreased resistance to bleomycin: decreased resistance to caffeine: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to mycophenolic acid: decreased resistance to dimethyl sulfoxide: decreased resistance to chloroquine: decreased resistance to mefloquine: decreased resistance to clioquinol: decreased resistance to cycloheximide: increased resistance to L-1,4-dithiothreitol: decreased resistance to calcium dichloride: decreased resistance to sorbate: decreased resistance to hygromycin B: decreased resistance to acrolein: decreased resistance to tunicamycin: decreased respiratory growth: decreased rate respiratory growth: decreased sporulation: abnormal vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	300 total interaction(s) for 187 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 2 Affinity Capture-Western: 6 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 6 Negative Genetic: 174 Phenotypic Enhancement: 1 Phenotypic Suppression: 3 Positive Genetic: 38 Synthetic Growth Defect: 31 Synthetic Lethality: 28
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:76583 to 71673 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4911 76583..71673 2005-11-07 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005241