MON1/YGL124C Summary Help

Standard Name MON1 1
Systematic Name YGL124C
Alias AUT12 2
Feature Type ORF, Verified
Description Protein required for cvt-vesicle/autophagosome fusion with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate (2, 3)
Name Description MONensin sensitivity 1
Chromosomal Location
ChrVII:276714 to 274780 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MON1 GO evidence and references
  View Computational GO annotations for MON1
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
212 total interaction(s) for 173 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Biochemical Activity: 1
  • Co-fractionation: 1
  • Two-hybrid: 13

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 128
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 2
  • Positive Genetic: 29
  • Synthetic Growth Defect: 14
  • Synthetic Lethality: 10

Resources
Expression Summary
histogram
Resources
Length (a.a.) 644
Molecular Weight (Da) 73,478
Isoelectric Point (pI) 7.32
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:276714 to 274780 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1935 276714..274780 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003092
References cited on this page View Complete Literature Guide for MON1
1) Muren E, et al.  (2001) Identification of yeast deletion strains that are hypersensitive to brefeldin A or monensin, two drugs that affect intracellular transport. Yeast 18(2):163-72
2) Meiling-Wesse K, et al.  (2002) Yeast Mon1p/Aut12p functions in vacuolar fusion of autophagosomes and cvt-vesicles. FEBS Lett 530(1-3):174-80
3) Wang CW, et al.  (2002) The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways. J Biol Chem 277(49):47917-27