MOG1/YJR074W Summary Help

Standard Name MOG1 1
Systematic Name YJR074W
Feature Type ORF, Verified
Description Conserved nuclear protein that interacts with GTP-Gsp1p; stimulates nucleotide release from Gsp1p; involved in nuclear protein import; nucleotide release is inhibited by Yrb1p (1, 2, 3)
Name Description Multicopy suppressor Of ts Gsp1 1
Chromosomal Location
ChrX:573095 to 573751 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MOG1 GO evidence and references
  View Computational GO annotations for MOG1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 9 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
210 total interaction(s) for 185 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 2
  • Co-purification: 1
  • PCA: 2
  • Reconstituted Complex: 4
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Rescue: 6
  • Negative Genetic: 123
  • Phenotypic Suppression: 1
  • Positive Genetic: 41
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 218
Molecular Weight (Da) 24,307
Isoelectric Point (pI) 4.41
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:573095 to 573751 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..657 573095..573751 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003835
References cited on this page View Complete Literature Guide for MOG1
1) Oki M and Nishimoto T  (1998) A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae ran homologue. Proc Natl Acad Sci U S A 95(26):15388-93
2) Stewart M and Baker RP  (2000) 1.9 A resolution crystal structure of the Saccharomyces cerevisiae Ran-binding protein Mog1p. J Mol Biol 299(1):213-23
3) Oki M and Nishimoto T  (2000) Yrb1p interaction with the gsp1p C terminus blocks Mog1p stimulation of GTP release from Gsp1p. J Biol Chem 275(42):32894-900