MNL2/YLR057W Summary Help

Standard Name MNL2 1
Systematic Name YLR057W
Feature Type ORF, Verified
Description Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene (1, 2)
Name Description MaNnosidase-Like protein 3
Chromosomal Location
ChrXII:255306 to 257855 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MNL2 GO evidence and references
  View Computational GO annotations for MNL2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
31 total interaction(s) for 30 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 1
  • Negative Genetic: 22
  • Positive Genetic: 1
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 849
Molecular Weight (Da) 96,996
Isoelectric Point (pI) 5.45
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:255306 to 257855 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2550 255306..257855 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004047
References cited on this page View Complete Literature Guide for MNL2
1) Benitez EM, et al.  (2011) Mnl2, a novel component of the ER associated protein degradation pathway. Biochem Biophys Res Commun 414(3):528-32
2) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3) Nakatsukasa K, et al.  (2001) Mnl1p, an alpha -mannosidase-like protein in yeast Saccharomyces cerevisiae, is required for endoplasmic reticulum-associated degradation of glycoproteins. J Biol Chem 276(12):8635-8