MNL2/YLR057W Summary Help

Standard Name MNL2 1
Systematic Name YLR057W
Feature Type ORF, Verified
Description Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene (1, 2)
Name Description MaNnosidase-Like protein 3
Chromosomal Location
ChrXII:255306 to 257855 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MNL2 GO evidence and references
  View Computational GO annotations for MNL2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 162 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
31 total interaction(s) for 30 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 1
  • Negative Genetic: 22
  • Positive Genetic: 1
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 849
Molecular Weight (Da) 96,996
Isoelectric Point (pI) 5.45
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:255306 to 257855 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2550 255306..257855 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004047
References cited on this page View Complete Literature Guide for MNL2
1) Benitez EM, et al.  (2011) Mnl2, a novel component of the ER associated protein degradation pathway. Biochem Biophys Res Commun 414(3):528-32
2) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3) Nakatsukasa K, et al.  (2001) Mnl1p, an alpha -mannosidase-like protein in yeast Saccharomyces cerevisiae, is required for endoplasmic reticulum-associated degradation of glycoproteins. J Biol Chem 276(12):8635-8