Standard Name	HPM1 1
Systematic Name	YIL110W
Alias	MNI1 2
Feature Type	ORF, Verified
Description	AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance (1, 3, 4, 5)
Name Description	Histidine Protein Methyltransferase 1

Chromosomal Location	ChrIX:156045 to 157178 | ORF Map | GBrowse

	View Computational GO annotations for HPM1
Molecular Function
Manually curated	protein-histidine N-methyltransferase activity (IMP) S-adenosylmethionine-dependent methyltransferase activity (ISS)
Biological Process
Manually curated	peptidyl-histidine methylation, to form tele-methylhistidine (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	Rpl3p modification: absent utilization of carbon source: increased rate
Large-scale survey
null	cell size: decreased glutathione excretion: increased chitin deposition: normal competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate metal resistance: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to acetic acid: increased resistance to benzo[a]pyrene: decreased resistance to cycloheximide: decreased resistance to selenomethionine: increased resistance to sorbate: increased sporulation efficiency: decreased stress resistance: increased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	27 total interaction(s) for 23 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1
Genetic Interactions	Negative Genetic: 15 Positive Genetic: 3 Synthetic Growth Defect: 3 Synthetic Lethality: 3 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:156045 to 157178 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1134 156045..157178 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001372