Standard Name	MMS1 1
Systematic Name	YPR164W
Alias	RTT108 2 , SLM6
Feature Type	ORF, Verified
Description	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay (2, 3, 4, 5, 6, 7, 8)
Name Description	Methyl MethaneSulfonate sensitivity

Chromosomal Location	ChrXVI:870703 to 874926 | ORF Map | GBrowse

	View Computational GO annotations for MMS1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	negative regulation of transposition, RNA-mediated (IMP) nonfunctional rRNA decay (IMP) recombinational repair (IMP) replication fork processing (IMP)
Cellular Component
Manually curated	Cul8-RING ubiquitin ligase complex (IDA)

Classical genetics
null	bud morphology: abnormal chromosome/plasmid maintenance: abnormal colony sectoring: increased gamma ray resistance: normal mitotic recombination: decreased mitotic recombination: normal Rad53p modification: increased resistance to methyl methanesulfonate: decreased resistance to camptothecin: decreased transposable element transposition: increased
reduction of function	UV resistance: normal X ray resistance: normal resistance to methyl methanesulfonate: decreased
Large-scale survey
null	cell cycle progression in G1 phase: decreased duration competitive fitness: decreased dessication resistance: decreased endocytosis: decreased heat sensitivity: increased mitotic recombination: increased Rad52-YFP distribution: increased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to neothyonidioside: decreased resistance to sodium arsenite: decreased resistance to camptothecin: decreased resistance to tirapazamine: decreased resistance to CTBT: decreased resistance to tunicamycin: increased resistance to mycophenolic acid: increased resistance to fluconazole: increased resistance to fenpropimorph: increased resistance to caffeine: increased resistance to cycloheximide: increased resistance to bleomycin: increased resistance to doxorubicin: decreased resistance to sodium selenide: decreased transposable element transposition: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	230 total interaction(s) for 144 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-Western: 10 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Negative Genetic: 95 Phenotypic Enhancement: 7 Phenotypic Suppression: 5 Positive Genetic: 16 Synthetic Growth Defect: 69 Synthetic Lethality: 10 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:870703 to 874926 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4224 870703..874926 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006368