MMM1/YLL006W Summary

MMM1/YLL006W Summary

Standard Name	MMM1 1
Systematic Name	YLL006W
Alias	YME6 2
Feature Type	ORF, Verified
Description	ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth (1, 3, 4, 5, 6)
Name Description	Maintenance of Mitochondrial Morphology 1

Chromosomal Location	ChrXII:136586 to 137866 \| ORF Map \| GBrowse

Gene Ontology Annotations All MMM1 GO evidence and references

	View Computational GO annotations for MMM1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	mitochondrial genome maintenance (IMP) mitochondrion organization (IMP) phospholipid transport (IGI, IMP) protein import into mitochondrial outer membrane (IMP)
Cellular Component
Manually curated	ERMES complex (IDA, IPI) integral to endoplasmic reticulum membrane (IDA) mitochondrial outer membrane (IDA)
High-throughput	mitochondrial outer membrane (IDA) mitochondrion (IDA)

Mutant phenotypes All MMM1 Phenotype evidence and references

Classical genetics
conditional	heat sensitivity: increased mitochondrial morphology: abnormal
null	phosphatidylethanolamine accumulation: decreased tellurium atom accumulation: decreased cardiolipin accumulation: decreased resistance to tellurite: increased respiratory growth: absent
Large-scale survey
null	cell size: decreased glycogen accumulation: decreased competitive fitness: decreased filamentous growth: decreased heat sensitivity: increased invasive growth: absent mitochondrial morphology: abnormal resistance to ethanol: decreased resistance to amiodarone: decreased resistance to trichothecene: increased resistance to acrolein: decreased resistance to calcium dichloride: decreased resistance to 2,4-dichlorophenol: decreased resistance to dimethyl sulfoxide: decreased resistance to glycolaldehyde: decreased respiratory growth: absent respiratory growth: decreased rate stress resistance: increased telomere length: decreased utilization of carbon source: decreased utilization of carbon source: absent vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All MMM1 Interaction evidence and references

	478 total interaction(s) for 387 unique genes/features.
Physical Interactions	Affinity Capture-MS: 33 Affinity Capture-Western: 16 PCA: 10
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 2 Negative Genetic: 306 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 78 Synthetic Growth Defect: 19 Synthetic Lethality: 8 Synthetic Rescue: 3
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DIP \| DRYGIN \| GeneMANIA \| InterologFinder

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All MMM1 Protein evidence and references

Localization	YeastRC \| Organelle DB (UMich) \| YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| AspGD Homologs \| CGD Homologs \| CandidaDB Homologs \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrXII:136586 to 137866 | |

SGD ORF map

Last Update

Coordinates: 2011-02-03 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1281	136586..137866	2011-02-03	1996-07-31

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000003929

References cited on this page View Complete Literature Guide for MMM1

1)	Burgess SM, et al. (1994) MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria. J Cell Biol 126(6):1375-91
2)	Hanekamp T, et al. (2002) Maintenance of mitochondrial morphology is linked to maintenance of the mitochondrial genome in Saccharomyces cerevisiae. Genetics 162(3):1147-56
3)	Boldogh I, et al. (1998) Interaction between mitochondria and the actin cytoskeleton in budding yeast requires two integral mitochondrial outer membrane proteins, Mmm1p and Mdm10p. J Cell Biol 141(6):1371-81
4)	Hobbs AE, et al. (2001) Mmm1p, a mitochondrial outer membrane protein, is connected to mitochondrial DNA (mtDNA) nucleoids and required for mtDNA stability. J Cell Biol 152(2):401-10
5)	Meisinger C, et al. (2007) The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J 26(9):2229-39
6)	Kornmann B, et al. (2009) An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 325(5939):477-81