MMF1/YIL051C Summary Help

Standard Name MMF1 1
Systematic Name YIL051C
Alias IBM1
Feature Type ORF, Verified
Description Mitochondrial protein required for transamination of isoleucine; but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; induction of expression in response to stress is mediated by a Hog1p-regulated antisense RNA and gene looping; interacts genetically with mitochondrial ribosomal protein genes; MMF1 has a paralog, HMF1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Mitochondrial Matrix Factor 1
Chromosomal Location
ChrIX:258280 to 257843 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All MMF1 GO evidence and references
  View Computational GO annotations for MMF1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 21 genes
Classical genetics
Large-scale survey
reduction of function
92 total interaction(s) for 86 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 17
  • Affinity Capture-RNA: 9
  • Biochemical Activity: 2
  • Co-crystal Structure: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 58
  • Synthetic Lethality: 1

Expression Summary
Length (a.a.) 145
Molecular Weight (Da) 15,908
Isoelectric Point (pI) 10.06
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIX:258280 to 257843 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..438 258280..257843 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001313
References cited on this page View Complete Literature Guide for MMF1
1) Oxelmark E, et al.  (2000) Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome. Mol Cell Biol 20(20):7784-97
2) Kim JM, et al.  (2001) A member of the YER057c/yjgf/Uk114 family links isoleucine biosynthesis and intact mitochondria maintenance in Saccharomyces cerevisiae. Genes Cells 6(6):507-17
3) Accardi R, et al.  (2004) High levels of the mitochondrial large ribosomal subunit protein 40 prevent loss of mitochondrial DNA in null mmf1 Saccharomyces cerevisiae cells. Yeast 21(7):539-48
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Nadal-Ribelles M, et al.  (2014) Control of Cdc28 CDK1 by a Stress-Induced lncRNA. Mol Cell 53(4):549-61