Standard Name	MLP2
Systematic Name	YIL149C
Feature Type	ORF, Verified
Description	Myosin-like protein associated with the nuclear envelope; connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; MLP2 has a paralog, MLP1, that arose from the whole genome duplication (1, 2, 3)
Name Description	Myosin-Like Protein 2

Chromosomal Location	ChrIX:68067 to 63028 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for MLP2
Molecular Function
Manually curated	ribonucleoprotein complex binding (IGI, IPI)
Biological Process
Manually curated	negative regulation of protein import into nucleus during spindle assembly checkpoint (IGI) poly(A)+ mRNA export from nucleus (IMP) posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery (IMP) regulation of transcription, DNA-dependent (IEP, IGI) spindle pole body organization (IMP) telomere tethering at nuclear periphery (IGI) transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery (IMP)
Cellular Component
Manually curated	nuclear envelope (IDA) nucleoplasm (IDA) colocalizes_with ribonucleoprotein complex (IPI) colocalizes_with spindle pole body (IDA) spindle pole body (IPI)
High-throughput	integral to membrane (ISM) mitochondrion (IDA)

Classical genetics
null	cell cycle progression in M phase: abnormal cellular morphology: abnormal nuclear export: abnormal position of spindle pole body: abnormal Spc42p accumulation: increased spindle morphology: abnormal telomere length: increased
Large-scale survey
null	competitive fitness: increased haploproficient resistance to quinine: increased resistance to camptothecin: increased resistance to hydroxyurea: increased resistance to bleomycin: decreased resistance to caffeine: decreased resistance to tunicamycin: decreased resistance to cycloheximide: increased resistance to cycloheximide: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	132 total interaction(s) for 87 unique genes/features.
Physical Interactions	Affinity Capture-MS: 44 Affinity Capture-RNA: 1 Affinity Capture-Western: 10 Biochemical Activity: 3 Co-localization: 1 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 1 Negative Genetic: 38 Phenotypic Enhancement: 7 Positive Genetic: 4 Synthetic Growth Defect: 5 Synthetic Lethality: 7 Synthetic Rescue: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:68067 to 63028 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..5040 68067..63028 1994-12-10 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001411