SUMMARY PARAGRAPH for MLH3
MLH3, one of four MutL homologs in S. cerevisiae, is involved in mismatch repair during mitosis and meiosis and plays a role in promoting crossing-over during meiotic recombination that is separate from its mismatch repair functions (reviewed in 5, 6). Like Pms1p and Mlh2p, two other MutL homologs, Mlh3p forms a heterodimer with Mlh1p, the fourth MutL homolog (7, 8, 2, 3). The Mlh1p-Mlh3p heterodimer is involved in the repair of specific types of mismatches (2, 1, 9) but its role in general mismatch repair is limited. An mlh3 mutant displays a reduced level of crossing-over during meiosis similar to an mlh1 single mutant, an msh4 single mutant, and an mlh1 msh4 double mutant, suggesting that the Mlh1p-Mlh3p heterodimer may interact with the Msh4p-Msh5p heterodimer to regulate cross-overs (10, 3). In addition, the Mlh1p-Mlh3p heterodimer may act to resolve cross-overs by interacting with the Sgs1p-Top3p heterodimer (11).
Last updated: 2007-05-29