MKC7/YDR144C Summary Help

Standard Name MKC7 1
Systematic Name YDR144C
Alias YPS2 2
Feature Type ORF, Verified
Description GPI-anchored aspartyl protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p; MKC7 has a paralog, YPS1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Multicopy suppressor of Kex2 Cold sensitivity 1
Chromosomal Location
ChrIV:746101 to 744311 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MKC7 GO evidence and references
  View Computational GO annotations for MKC7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
45 total interaction(s) for 34 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 1
  • Co-purification: 1

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 19
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 2
  • Positive Genetic: 2
  • Synthetic Growth Defect: 4
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 596
Molecular Weight (Da) 64,269
Isoelectric Point (pI) 4.4
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:746101 to 744311 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1791 746101..744311 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002551
References cited on this page View Complete Literature Guide for MKC7
1) Komano H and Fuller RS  (1995) Shared functions in vivo of a glycosyl-phosphatidylinositol-linked aspartyl protease, Mkc7, and the proprotein processing protease Kex2 in yeast. Proc Natl Acad Sci U S A 92(23):10752-6
2) Komano H, et al.  (1999) Purification and characterization of the yeast glycosylphosphatidylinositol-anchored, monobasic-specific aspartyl protease yapsin 2 (Mkc7p). J Biol Chem 274(34):24431-7
3) Krysan DJ, et al.  (2005) Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae. Eukaryot Cell 4(8):1364-74
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61