MIS1/YBR084W Summary

MIS1 BASIC INFORMATION

Standard Name	MIS1 1
Systematic Name	YBR084W
Feature Type	ORF, Verified
Description	Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase (1)
Name Description	MItochondrial C1-tetrahydrofolate Synthase 1

GO Annotations	All MIS1 GO evidence and references
	View Computational GO annotations for MIS1
Molecular Function
Manually curated	formate-tetrahydrofolate ligase activity (IDA) methenyltetrahydrofolate cyclohydrolase activity (IDA) methionyl-tRNA formyltransferase activity (IMP) methylenetetrahydrofolate dehydrogenase (NADP+) activity (IDA)
Biological Process
Manually curated	folic acid biosynthetic process (IDA) nucleobase, nucleoside, nucleotide and nucleic acid metabolic process (IMP)
Cellular Component
Manually curated	mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Pathways	folate biosynthesis folate polyglutamylation pathways of chorismate

Mutant Phenotype	All MIS1 Phenotype details and references
Classical genetics
null	respiratory growth: decreased rate viable
Large-scale survey
null	resistance to oleate: decreased respiratory growth: decreased rate viable

Interactions	MIS1 All interactions details and references
	47 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 43 Affinity Capture-Western: 1
Genetic Interactions	Synthetic Growth Defect: 2 Synthetic Lethality: 1

Sequence Information

ChrII:411048 to 413975 | |

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2928	411048..413975	2004-07-16	1997-01-28

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000288

MIS1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for MIS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MIS1]

1)	Shannon KW and Rabinowitz JC (1988) Isolation and characterization of the Saccharomyces cerevisiae MIS1 gene encoding mitochondrial C1-tetrahydrofolate synthase. J Biol Chem 263(16):7717-25

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