MIP1/YOR330C Summary Help

MIP1 BASIC INFORMATION

Standard Name MIP1 1
Systematic Name YOR330C
Feature Type ORF, Verified
Description Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; related to human POLG, which has been associated with mitochondrial diseases (1, 2, 3)
Name Description MItochondrial DNA Polymerase
Gene Product Alias mitochondrial DNA polymerase catalytic subunit 1
GO Annotations All MIP1 GO evidence and references
    View Computational GO annotations for MIP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All MIP1 Phenotype details and references
Classical genetics
dominant negative
gain of function
null
reduction of function
Large-scale survey
null
Interactions MIP1 All interactions details and references
34 total interaction(s) for 31 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 1
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 10
  • Phenotypic Suppression: 16
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1
Sequence Information
ChrXV:943382 to 939618 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 181 cM
Last Update Coordinates: 2006-01-05 | Sequence: 2005-11-30
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3765 943382..939618 2006-01-05 2005-11-30
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005857

MIP1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for MIP1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
OCT1Nomenclature conflictMIP1 has been used to refer to both MIP1/YOR330C, which encodes the mitochondrial DNA polymerase, and OCT1/YKL134C, which encodes the mitochondrial intermediate peptidase.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MIP1]

1) Foury F  (1989) Cloning and sequencing of the nuclear gene MIP1 encoding the catalytic subunit of the yeast mitochondrial DNA polymerase. J Biol Chem 264(34):20552-60
2) Stuart GR, et al.  (2006) Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase gamma associated with progressive external ophthalmoplegia. Hum Mol Genet 15(2):363-74
3) Young MJ, et al.  (2006) The carboxyl-terminal extension on fungal mitochondrial DNA polymerases: identification of a critical region of the enzyme from Saccharomyces cerevisiae. Yeast 23(2):101-16