MIG2/YGL209W Summary Help

Standard Name MIG2 1
Systematic Name YGL209W
Alias MLZ1 2
Feature Type ORF, Verified
Description Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication (1, 3, 4, 5)
Name Description Multicopy Inhibitor of GAL gene expression
Chromosomal Location
ChrVII:95858 to 97006 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MIG2 GO evidence and references
  View Computational GO annotations for MIG2
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Targets 1 genes
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
45 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 6
  • Biochemical Activity: 4
  • PCA: 1
  • Protein-RNA: 2
  • Reconstituted Complex: 2
  • Two-hybrid: 4

Genetic Interactions
  • Negative Genetic: 10
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 4
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 382
Molecular Weight (Da) 42,048
Isoelectric Point (pI) 10.5
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:95858 to 97006 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1149 95858..97006 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003177
References cited on this page View Complete Literature Guide for MIG2
1) Lutfiyya LL and Johnston M  (1996) Two zinc-finger-containing repressors are responsible for glucose repression of SUC2 expression. Mol Cell Biol 16(9):4790-7
2) Kail M, et al.  (1996) Lambda clone B22 contains a 7676 bp genomic fragment of Saccharomyces cerevisiae chromosome VII spanning the VAM7-SPM2 intergenic region and containing three novel transcribed open reading frames. Yeast 12(8):799-807
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Fernandez-Cid A, et al.  (2012) Glucose levels regulate the nucleo-mitochondrial distribution of Mig2. Mitochondrion 12(3):370-80
5) Karunanithi S and Cullen PJ  (2012) The filamentous growth MAPK Pathway Responds to Glucose Starvation Through the Mig1/2 transcriptional repressors in Saccharomyces cerevisiae. Genetics 192(3):869-87
6) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87
7) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66