MIG2/YGL209W Summary Help

Standard Name MIG2 1
Systematic Name YGL209W
Alias MLZ1 2
Feature Type ORF, Verified
Description Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication (1, 3, 4, 5)
Name Description Multicopy Inhibitor of GAL gene expression
Chromosomal Location
ChrVII:95858 to 97006 | ORF Map | GBrowse
Gene Ontology Annotations All MIG2 GO evidence and references
  View Computational GO annotations for MIG2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 333 genes
Regulators 128 genes
Classical genetics
Large-scale survey
43 total interaction(s) for 30 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 6
  • Biochemical Activity: 4
  • PCA: 1
  • Protein-RNA: 2
  • Reconstituted Complex: 2
  • Two-hybrid: 4

Genetic Interactions
  • Negative Genetic: 10
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 4
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 382
Molecular Weight (Da) 42,048
Isoelectric Point (pI) 10.5
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:95858 to 97006 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1149 95858..97006 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003177
References cited on this page View Complete Literature Guide for MIG2
1) Lutfiyya LL and Johnston M  (1996) Two zinc-finger-containing repressors are responsible for glucose repression of SUC2 expression. Mol Cell Biol 16(9):4790-7
2) Kail M, et al.  (1996) Lambda clone B22 contains a 7676 bp genomic fragment of Saccharomyces cerevisiae chromosome VII spanning the VAM7-SPM2 intergenic region and containing three novel transcribed open reading frames. Yeast 12(8):799-807
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Fernandez-Cid A, et al.  (2012) Glucose levels regulate the nucleo-mitochondrial distribution of Mig2. Mitochondrion 12(3):370-80
5) Karunanithi S and Cullen PJ  (2012) The filamentous growth MAPK Pathway Responds to Glucose Starvation Through the Mig1/2 transcriptional repressors in Saccharomyces cerevisiae. Genetics 192(3):869-87
6) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87
7) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66