Standard Name	MIA40 1
Systematic Name	YKL195W
Alias	FMP15 , TIM40 2
Feature Type	ORF, Verified
Description	Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p (1, 3, 4, 5)
Name Description	Mitochondrial intermembrane space Import and Assembly 1

Chromosomal Location	ChrXI:75821 to 77032 | ORF Map | GBrowse

	View Computational GO annotations for MIA40
Molecular Function
Manually curated	oxidoreductase activity (IMP)
Biological Process
Manually curated	protein folding (IDA) protein import into mitochondrial intermembrane space (IMP, IPI)
Cellular Component
Manually curated	mitochondrial inner membrane (IDA) mitochondrial intermembrane space (IDA) mitochondrial outer membrane translocase complex (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
conditional	heat sensitivity: increased Tim22p accumulation: decreased
null	inviable
repressible	mitochondrial transport: decreased Cmc1p distribution: abnormal
Large-scale survey
conditional	heat sensitivity: increased
null	inviable vegetative growth: decreased
overexpression	cell cycle progression: abnormal vegetative growth: decreased rate vegetative growth: decreased
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	118 total interaction(s) for 71 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-RNA: 3 Affinity Capture-Western: 22 Biochemical Activity: 8 Co-fractionation: 1 Co-purification: 16 Reconstituted Complex: 19
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 2 Negative Genetic: 28 Phenotypic Enhancement: 1 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:75821 to 77032 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1212 75821..77032 2011-02-03 2003-09-22
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001678