Standard Name	MHR1
Systematic Name	YDR296W
Alias	XTC1 1
Feature Type	ORF, Verified
Description	Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress (2, 3, 4, 5)
Name Description	Mitochondrial Homologous DNA Recombination

Chromosomal Location	ChrIV:1055212 to 1055892 | ORF Map | GBrowse

	View Computational GO annotations for MHR1
Molecular Function
Manually curated	DNA binding (IDA) recombinase activity (IDA, IMP) single-stranded DNA binding (IDA)
Biological Process
Manually curated	cellular response to oxidative stress (IMP) DNA recombination (IMP) mitochondrial genome maintenance (IDA, IGI) positive regulation of mitochondrial DNA replication (IMP) regulation of transcription, DNA-dependent (IPI)
Cellular Component
Manually curated	mitochondrion (IDA) nucleus (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
conditional	mitochondrial genome maintenance: decreased
null	heat sensitivity: increased mitochondrial genome maintenance: abnormal resistance to erythromycin estolate: increased
Large-scale survey
null	acid pH resistance: decreased cell cycle progression in G1 phase: delayed glycogen accumulation: decreased polyphosphate accumulation: abnormal competitive fitness: decreased filamentous growth: decreased haploproficient heat sensitivity: increased mitochondrial morphology: abnormal Fus-Mid-GFP distribution: abnormal resistance to trichothecene: increased resistance to paromomycin: decreased resistance to 2,4-dichlorophenol: decreased resistance to cycloheximide: decreased resistance to acrolein: decreased respiratory growth: absent respiratory growth: decreased rate stress resistance: increased utilization of carbon source: decreased utilization of carbon source: absent vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	76 total interaction(s) for 49 unique genes/features.
Physical Interactions	Affinity Capture-MS: 59 Affinity Capture-RNA: 4 PCA: 1 Reconstituted Complex: 1 Two-hybrid: 3
Genetic Interactions	Phenotypic Enhancement: 5 Synthetic Growth Defect: 1 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1055212 to 1055892 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..681 1055212..1055892 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002704