MHF1/YOL086W-A Summary Help

Standard Name MHF1 1, 2
Systematic Name YOL086W-A
Feature Type ORF, Verified
Description Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1 (1, 2, 3)
Name Description Mph1-associated Histone-Fold protein 1
Chromosomal Location
ChrXV:159173 to 159445 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MHF1 GO evidence and references
  View Computational GO annotations for MHF1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Large-scale survey
null
Resources
20 total interaction(s) for 8 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4
  • Co-crystal Structure: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Synthetic Growth Defect: 3
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 90
Molecular Weight (Da) 10,549
Isoelectric Point (pI) 5.25
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:159173 to 159445 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2006-01-05 | Sequence: 2001-02-26
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..273 159173..159445 2006-01-05 2001-02-26
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000007626
References cited on this page View Complete Literature Guide for MHF1
1) Yan Z, et al.  (2010) A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol Cell 37(6):865-78
2) Yang H, et al.  (2012) Saccharomyces Cerevisiae MHF Complex Structurally Resembles the Histones (H3-H4)(2) Heterotetramer and Functions as a Heterotetramer. Structure 20(2):364-70
3) Schleiffer A, et al.  (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13