MGR3/YMR115W Summary Help

Standard Name MGR3 1
Systematic Name YMR115W
Alias FMP24 2
Feature Type ORF, Verified
Description Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA (1, 3)
Name Description Mitochondrial Genome Required 1
Chromosomal Location
ChrXIII:497704 to 499209 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MGR3 GO evidence and references
  View Computational GO annotations for MGR3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
141 total interaction(s) for 89 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 3
  • Biochemical Activity: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 108
  • Phenotypic Enhancement: 1
  • Positive Genetic: 11
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 1
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 501
Molecular Weight (Da) 58,003
Isoelectric Point (pI) 8.56
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:497704 to 499209 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1506 497704..499209 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004721
References cited on this page View Complete Literature Guide for MGR3
1) Dunn CD, et al.  (2008) Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex. Mol Biol Cell 19(12):5387-97
2) Frederick RL, et al.  (2008) Multiple pathways influence mitochondrial inheritance in budding yeast. Genetics 178(2):825-37
3) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54