MGR2/YPL098C Summary Help

Standard Name MGR2 1
Systematic Name YPL098C
Feature Type ORF, Verified
Description Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype) (1, 2)
Name Description Mitochondrial Genome Required 1
Chromosomal Location
ChrXVI:364727 to 364386 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MGR2 GO evidence and references
  View Computational GO annotations for MGR2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
108 total interaction(s) for 88 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-Western: 3

Genetic Interactions
  • Negative Genetic: 89
  • Positive Genetic: 8
  • Synthetic Growth Defect: 5
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 113
Molecular Weight (Da) 12,252
Isoelectric Point (pI) 10.53
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:364727 to 364386 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..342 364727..364386 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006019
References cited on this page View Complete Literature Guide for MGR2
1) Dunn CD, et al.  (2006) A genomewide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex. Mol Biol Cell 17(1):213-26
2) Gebert M, et al.  (2012) Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes. J Cell Biol 197(5):595-604