Standard Name	MGA2
Systematic Name	YIR033W
Feature Type	ORF, Verified
Description	ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; MGA2 has a paralog, SPT23, that arose from the whole genome duplication (1, 2, 3)
Name Description	Multicopy suppressor of GAm1 (snf2) 4

Chromosomal Location	ChrIX:416124 to 419465 | ORF Map | GBrowse

	View Computational GO annotations for MGA2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cellular response to cold (IMP) chromatin silencing at silent mating-type cassette (IGI) mRNA stabilization (IMP) positive regulation of transcription from RNA polymerase II promoter (IMP) positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion (IMP) positive regulation of transcription from RNA polymerase II promoter in response to hypoxia (IMP) positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter (IGI)
Cellular Component
Manually curated	integral to endoplasmic reticulum membrane (IDA, ISM) nucleus (IDA)

Classical genetics
null	tellurium atom accumulation: increased metal resistance: decreased resistance to tellurite: decreased resistance to ferrozine(2-): decreased resistance to cobalt chloride hexahydrate: decreased viable
Large-scale survey
null	alkaline pH resistance: decreased anaerobic growth: decreased cell cycle progression through the G2/M phase transition: delayed competitive fitness: decreased heat sensitivity: increased protein transport: abnormal resistance to caffeine: decreased resistance to bleomycin: decreased resistance to methyl methanesulfonate: decreased resistance to CTBT: decreased resistance to fenpropimorph: increased resistance to tirapazamine: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to paromomycin: decreased resistance to benzo[a]pyrene: increased resistance to benzo[a]pyrene: decreased resistance to hydroxyurea: decreased resistance to sirolimus: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased resistance to BPS: decreased resistance to St. John's Wort extract: decreased stress resistance: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	362 total interaction(s) for 212 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 2 Affinity Capture-Western: 4 Biochemical Activity: 2 PCA: 1 Reconstituted Complex: 3 Two-hybrid: 20
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 3 Negative Genetic: 122 Phenotypic Enhancement: 28 Phenotypic Suppression: 99 Positive Genetic: 42 Synthetic Growth Defect: 15 Synthetic Lethality: 10 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:416124 to 419465 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3342 416124..419465 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001472