MFM1/YPL060W Summary Help

Standard Name MFM1 1
Systematic Name YPL060W
Alias LPE10
Feature Type ORF, Verified
Description Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p (1, 2)
Name Description Mrs2 Function Modulating factor 1
Chromosomal Location
ChrXVI:434523 to 435764 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MFM1 GO evidence and references
  View Computational GO annotations for MFM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
59 total interaction(s) for 48 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-Western: 2

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 1
  • Negative Genetic: 49
  • Positive Genetic: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 413
Molecular Weight (Da) 47,082
Isoelectric Point (pI) 9.34
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:434523 to 435764 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1242 434523..435764 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000005981
References cited on this page View Complete Literature Guide for MFM1
1) Sponder G, et al.  (2010) Lpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mgchannel. FEBS J 277(17):3514-25
2) Gregan J, et al.  (2001) The mitochondrial inner membrane protein Lpe10p, a homologue of Mrs2p, is essential for magnesium homeostasis and group II intron splicing in yeast. Mol Gen Genet 264(6):773-81