MF(ALPHA)1/YPL187W Summary Help

Standard Name MF(ALPHA)1 1, 2, 3
Systematic Name YPL187W
Feature Type ORF, Verified
Description Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor; MF(ALPHA)1 has a paralog, MF(ALPHA)2, that arose from the whole genome duplication (1, 4, 5)
Name Description Mating Factor ALPHA 6
Gene Product Alias alpha factor 7
Chromosomal Location
ChrXVI:193648 to 194145 | ORF Map | GBrowse
Genetic position: -115 cM
  View Computational GO annotations for MF(ALPHA)1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 9 genes
Classical genetics
Large-scale survey
9 total interaction(s) for 7 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Co-purification: 1
  • Reconstituted Complex: 1

Genetic Interactions
  • Negative Genetic: 1
  • Synthetic Growth Defect: 2

Expression Summary
Length (a.a.) 165
Molecular Weight (Da) 18,642
Isoelectric Point (pI) 4.81
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXVI:193648 to 194145 | ORF Map | GBrowse
Genetic position: -115 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..498 193648..194145 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006108
References cited on this page View Complete Literature Guide for MF(ALPHA)1
1) Singh A, et al.  (1983) Saccharomyces cerevisiae contains two discrete genes coding for the alpha-factor pheromone. Nucleic Acids Res 11(12):4049-63
2) Fassler, J.  (1992) Personal Communication, Mortimer Map Edition 11
3) Michaelis, S.  (1993) Personal Communication, Mortimer Map Edition 12
4) Kurjan J  (1985) Alpha-factor structural gene mutations in Saccharomyces cerevisiae: effects on alpha-factor production and mating. Mol Cell Biol 5(4):787-96
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Kurjan J and Herskowitz I  (1982) Structure of a yeast pheromone gene (MF alpha): a putative alpha-factor precursor contains four tandem copies of mature alpha-factor. Cell 30(3):933-43
7) Stotzler D and Duntze W  (1976) Isolation and characterization of four related peptides exhibiting alpha factor activity from Saccharomyces cerevisiae. Eur J Biochem 65(1):257-62