MET6/YER091C Summary Help

Standard Name MET6 1
Systematic Name YER091C
Feature Type ORF, Verified
Description Cobalamin-independent methionine synthase; involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs (2, 3)
Name Description METhionine requiring 1
Chromosomal Location
ChrV:342167 to 339864 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 77 cM
Gene Ontology Annotations All MET6 GO evidence and references
  View Computational GO annotations for MET6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 20 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
overexpression
Resources
107 total interaction(s) for 85 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 18
  • Affinity Capture-RNA: 5
  • PCA: 2
  • Reconstituted Complex: 1

Genetic Interactions
  • Negative Genetic: 65
  • Phenotypic Enhancement: 2
  • Positive Genetic: 12
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 767
Molecular Weight (Da) 85,859
Isoelectric Point (pI) 6.42
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:342167 to 339864 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: 77 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2304 342167..339864 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000893
References cited on this page View Complete Literature Guide for MET6
1) Masselot M and De Robichon-Szulmajster H  (1975) Methionine biosynthesis in Saccharomyces cerevisiae. I. Genetical analysis of auxotrophic mutants. Mol Gen Genet 139(2):121-32
2) Smith V, et al.  (1996) Functional analysis of the genes of yeast chromosome V by genetic footprinting. Science 274(5295):2069-74
3) Suliman HS, et al.  (2005) Purification and properties of cobalamin-independent methionine synthase from Candida albicans and Saccharomyces cerevisiae. Arch Biochem Biophys 441(1):56-63