MET6/YER091C Summary

MET6 BASIC INFORMATION

Standard Name	MET6 1
Systematic Name	YER091C
Feature Type	ORF, Verified
Description	Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs (2, 3)
Name Description	METhionine requiring 1

GO Annotations	All MET6 GO evidence and references
	View Computational GO annotations for MET6
Molecular Function
Manually curated	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity (IMP)
Biological Process
Manually curated	methionine biosynthetic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) plasma membrane enriched fraction (IDA)

Pathways	methionine biosynthesis S-adenosylmethionine cycle superpathway of methionine biosynthesis superpathway of sulfur amino acid biosynthesis superpathway of threonine and methionine biosynthesis

Mutant Phenotype	All MET6 Phenotype details and references
Classical genetics
null	auxotrophy
Large-scale survey
null	competitive fitness: decreased resistance to sulfanilamide: decreased viable

Interactions	MET6 All interactions details and references
	16 total interaction(s) for 16 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Reconstituted Complex: 1
Genetic Interactions	Phenotypic Enhancement: 2 Synthetic Growth Defect: 1

Sequence Information

ChrV:342163 to 339860 | |

Note: this feature is encoded on the Crick strand.

Genetic position: 77 cM

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2304	342163..339860	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000893

MET6 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MET6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MET6]

1)	Masselot M and De Robichon-Szulmajster H (1975) Methionine biosynthesis in Saccharomyces cerevisiae. I. Genetical analysis of auxotrophic mutants. Mol Gen Genet 139(2):121-32
2)	Smith V, et al. (1996) Functional analysis of the genes of yeast chromosome V by genetic footprinting. Science 274(5295):2069-74
3)	Suliman HS, et al. (2005) Purification and properties of cobalamin-independent methionine synthase from Candida albicans and Saccharomyces cerevisiae. Arch Biochem Biophys 441(1):56-63

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