Standard Name	MET30 1
Systematic Name	YIL046W
Alias	ZRG11 2
Feature Type	ORF, Verified
Description	F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus (3, 4)
Name Description	METhionine requiring

Chromosomal Location	ChrIX:268651 to 270573 | ORF Map | GBrowse

	View Computational GO annotations for MET30
Molecular Function
Manually curated	ubiquitin binding (IDA)
Biological Process
Manually curated	G1/S transition of mitotic cell cycle (IMP) M phase of mitotic cell cycle (IMP) protein polyubiquitination (IMP) protein ubiquitination (IGI, IPI) regulation of DNA-dependent DNA replication initiation (IMP) regulation of transcription involved in G1 phase of mitotic cell cycle (IMP) response to arsenic-containing substance (IDA) response to cadmium ion (IDA) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (IGI)
Cellular Component
Manually curated	nuclear SCF ubiquitin ligase complex (IDA) nucleus (IDA) SCF ubiquitin ligase complex (IDA)

Classical genetics
conditional	heat sensitivity: increased mitotic cell cycle: arrested Swe1p-myc12 accumulation: increased
null	inviable
overexpression	resistance to methylmercury chloride: normal
Large-scale survey
null	inviable resistance to sulfanilamide: decreased
reduction of function	competitive fitness: decreased
repressible	chromosome/plasmid maintenance: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	167 total interaction(s) for 106 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-Western: 27 Co-localization: 3 PCA: 1 Reconstituted Complex: 2 Two-hybrid: 18
Genetic Interactions	Dosage Lethality: 6 Dosage Rescue: 6 Negative Genetic: 67 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 1 Synthetic Growth Defect: 3 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 8 Synthetic Rescue: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:268651 to 270573 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1923 268651..270573 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001308