MET3/YJR010W Summary

MET3 BASIC INFORMATION

Standard Name	MET3 1
Systematic Name	YJR010W
Feature Type	ORF, Verified
Description	ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism (2, 3)
Name Description	METhionine requiring 1

GO Annotations	All MET3 GO evidence and references
	View Computational GO annotations for MET3
Molecular Function
Manually curated	sulfate adenylyltransferase (ATP) activity (TAS)
Biological Process
Manually curated	methionine metabolic process (IMP) sulfate assimilation (TAS)
Cellular Component
High-throughput	cytoplasm (IDA) mitochondrion (IDA)

Pathways	sulfate assimilation pathway superpathway of sulfur amino acid biosynthesis

Mutant Phenotype	All MET3 Phenotype details and references
Classical genetics
null	auxotrophy
Large-scale survey
null	glycogen accumulation: increased competitive fitness: decreased resistance to amiodarone: decreased viable

Interactions	MET3 All interactions details and references
	11 total interaction(s) for 8 unique genes/features.
Physical Interactions	Co-crystal Structure: 1 Reconstituted Complex: 1 Two-hybrid: 5
Genetic Interactions	Synthetic Growth Defect: 1 Synthetic Lethality: 2 Synthetic Rescue: 1

Sequence Information

ChrX:456231 to 457766 | |

Genetic position: 3 cM

Last Update

Coordinates: 2009-02-18 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1536	456231..457766	2009-02-18	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003771

MET3 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for MET3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MET3]

1)	Masselot M and De Robichon-Szulmajster H (1975) Methionine biosynthesis in Saccharomyces cerevisiae. I. Genetical analysis of auxotrophic mutants. Mol Gen Genet 139(2):121-32
2)	Cherest H, et al. (1985) Transcriptional regulation of the MET3 gene of Saccharomyces cerevisiae. Gene 34(2-3):269-81
3)	Ullrich TC, et al. (2001) Crystal structure of ATP sulfurylase from Saccharomyces cerevisiae, a key enzyme in sulfate activation. EMBO J 20(3):316-29

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