MER1/YNL210W Summary Help

Standard Name MER1 1
Systematic Name YNL210W
Feature Type ORF, Verified
Description mRNA-binding protein required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination; Mer1p regulon embraces four essential meiotic pre-mRNAs: REC107, HFM1, AMA1 and SPO22 (2, 3, 4, 5)
Name Description MEiotic Recombination 1
Chromosomal Location
ChrXIV:250931 to 251743 | ORF Map | GBrowse
Gbrowse
Genetic position: -138 cM
Gene Ontology Annotations All MER1 GO evidence and references
  View Computational GO annotations for MER1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
16 total interaction(s) for 14 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Protein-RNA: 1
  • Two-hybrid: 10

Genetic Interactions
  • Dosage Rescue: 1
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 270
Molecular Weight (Da) 31,111
Isoelectric Point (pI) 7.42
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:250931 to 251743 | ORF Map | GBrowse
SGD ORF map
Genetic position: -138 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..813 250931..251743 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005154
References cited on this page View Complete Literature Guide for MER1
1) Engebrecht J and Roeder GS  (1989) Yeast mer1 mutants display reduced levels of meiotic recombination. Genetics 121(2):237-47
2) Engebrecht JA, et al.  (1991) Meiosis-specific RNA splicing in yeast. Cell 66(6):1257-68
3) Engebrecht J and Roeder GS  (1990) MER1, a yeast gene required for chromosome pairing and genetic recombination, is induced in meiosis. Mol Cell Biol 10(5):2379-89
4) Spingola M and Ares M Jr  (2000) A yeast intronic splicing enhancer and Nam8p are required for Mer1p-activated splicing. Mol Cell 6(2):329-38
5) Qiu ZR, et al.  (2011) Defining the Mer1 and Nam8 meiotic splicing regulons by cDNA rescue. RNA 17(9):1648-54