MEP2/YNL142W Summary

MEP2 BASIC INFORMATION

Standard Name	MEP2
Systematic Name	YNL142W
Feature Type	ORF, Verified
Description	Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation (1, 2)

GO Annotations	All MEP2 GO evidence and references
	View Computational GO annotations for MEP2
Molecular Function
Manually curated	ammonium transmembrane transporter activity (IDA, IMP)
Biological Process
Manually curated	ammonium transport (IMP) nitrogen utilization (IMP) pseudohyphal growth (IMP)
Cellular Component
Manually curated	plasma membrane (IDA)

Mutant Phenotype	All MEP2 Phenotype details and references
Classical genetics
null	trehalose accumulation: increased glycogen accumulation: increased chronological lifespan: increased oxidative stress resistance: increased pseudohyphal growth: absent pseudohyphal growth: decreased thermotolerance: increased
Large-scale survey
null	viable
overexpression	filamentous growth: increased

Interactions	MEP2 All interactions details and references
	28 total interaction(s) for 19 unique genes/features.
Physical Interactions	Affinity Capture-Western: 1
Genetic Interactions	Dosage Rescue: 20 Phenotypic Suppression: 1 Synthetic Growth Defect: 2 Synthetic Lethality: 4

Sequence Information

ChrXIV:357455 to 358954 | |

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1500	357455..358954	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| TCDB \| UniProtKB

Primary SGDID	S000005086

MEP2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MEP2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MEP2]

1)	Marini AM, et al. (1997) A family of ammonium transporters in Saccharomyces cerevisiae. Mol Cell Biol 17(8):4282-93
2)	Lorenz MC and Heitman J (1998) The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae. EMBO J 17(5):1236-47

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