Standard Name	MEH1 1
Systematic Name	YKR007W
Alias	EGO1 2 , GSE2 3
Feature Type	ORF, Verified
Description	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification (1, 2, 3)
Name Description	Multicopy suppressor of Ers1 Hygromycin B sensitivity 1

Chromosomal Location	ChrXI:451434 to 451988 | ORF Map | GBrowse

	View Computational GO annotations for MEH1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	microautophagy (IMP) vacuolar acidification (IMP)
Cellular Component
Manually curated	EGO complex (IDA, IPI) fungal-type vacuole membrane (IDA) late endosome membrane (IDA)
High-throughput	fungal-type vacuole membrane (IDA)

Classical genetics
null	nutrient uptake: decreased resistance to hygromycin B: decreased survival rate in stationary phase: decreased viable
unspecified	Gap1p distribution: abnormal
Large-scale survey
null	auxotrophy glycogen accumulation: increased competitive fitness: decreased haploproficient heat sensitivity: increased lifespan: increased resistance to caffeine: decreased resistance to arsenite(3-): decreased resistance to ethanol: decreased resistance to wortmannin: decreased resistance to sirolimus: decreased resistance to mycophenolic acid: increased resistance to cycloheximide: decreased resistance to streptomycin: decreased resistance to hygromycin B: decreased resistance to acetic acid: decreased resistance to spermine: decreased resistance to bleomycin: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to sorbate: decreased resistance to acrolein: decreased starvation resistance: decreased stress resistance: increased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	162 total interaction(s) for 121 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 2 Affinity Capture-Western: 6 Biochemical Activity: 2 Co-fractionation: 2 PCA: 17 Reconstituted Complex: 5 Two-hybrid: 10
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 65 Phenotypic Suppression: 26 Positive Genetic: 12 Synthetic Growth Defect: 5 Synthetic Lethality: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:451434 to 451988 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..555 451434..451988 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001715