Standard Name	MDY2 1
Systematic Name	YOL111C
Alias	TMA24 2 , GET5 3
Feature Type	ORF, Verified
Description	Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes (1, 2, 3, 4)
Name Description	Mating-Deficient Yeast 1, 2

Chromosomal Location	ChrXV:108896 to 108258 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for MDY2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cell morphogenesis involved in conjugation with cellular fusion (IMP) posttranslational protein targeting to membrane (IDA) protein insertion into ER membrane (IGI)
Cellular Component
Manually curated	nucleus (IDA) colocalizes_with ribosome (IDA) TRC complex (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	heat sensitivity: increased mating efficiency: decreased Hsp104p accumulation: increased CPY modification: decreased resistance to hygromycin B: decreased stress resistance: decreased
Large-scale survey
null	acid pH resistance: decreased auxotrophy competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased protein transport: abnormal resistance to amitrole: decreased resistance to ethanol: decreased resistance to hydrogen chloride: decreased resistance to cycloheximide: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	172 total interaction(s) for 80 unique genes/features.
Physical Interactions	Affinity Capture-MS: 23 Affinity Capture-RNA: 2 Affinity Capture-Western: 16 Co-crystal Structure: 3 Co-purification: 2 Reconstituted Complex: 5 Two-hybrid: 11
Genetic Interactions	Negative Genetic: 29 Phenotypic Enhancement: 53 Phenotypic Suppression: 16 Positive Genetic: 5 Synthetic Growth Defect: 6 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:108896 to 108258 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..639 108896..108258 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005471