Standard Name	MDV1 1
Systematic Name	YJL112W
Alias	FIS2 2 , GAG3 , NET2
Feature Type	ORF, Verified
Description	Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication (1, 3, 4, 5)
Name Description	Mitochondrial DiVision 1

Chromosomal Location	ChrX:205305 to 207449 | ORF Map | GBrowse

	View Computational GO annotations for MDV1
Molecular Function
Manually curated	ubiquitin binding (IDA)
Biological Process
Manually curated	mitochondrial fission (IGI, IMP, IPI) mitochondrial genome maintenance (IGI, IMP) peroxisome fission (IGI)
Cellular Component
Manually curated	mitochondrial outer membrane (IDA)
High-throughput	mitochondrial outer membrane (IDA) mitochondrion (IDA)

Classical genetics
null	apoptosis: decreased resistance to BAR0329: increased viability: decreased
reduction of function	mitochondrial morphology: abnormal
Large-scale survey
null	competitive fitness: increased mitochondrial morphology: abnormal resistance to arsenite(3-): decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	115 total interaction(s) for 56 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-Western: 14 Co-crystal Structure: 2 Co-localization: 4 Co-purification: 1 PCA: 2 Reconstituted Complex: 3 Two-hybrid: 48
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 18 Phenotypic Enhancement: 11 Phenotypic Suppression: 2 Positive Genetic: 1 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:205305 to 207449 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2145 205305..207449 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003648