MDS3/YGL197W Summary Help

Standard Name MDS3 1
Systematic Name YGL197W
Feature Type ORF, Verified
Description Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain; MDS3 has a paralog, PMD1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Mck1 Dosage Suppressor 1
Chromosomal Location
ChrVII:124698 to 129161 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MDS3 GO evidence and references
  View Computational GO annotations for MDS3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
unspecified
Resources
101 total interaction(s) for 77 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 30
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Protein-RNA: 1
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 40
  • Phenotypic Enhancement: 2
  • Positive Genetic: 11
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 1
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,487
Molecular Weight (Da) 166,971
Isoelectric Point (pI) 7.47
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:124698 to 129161 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4464 124698..129161 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003165
References cited on this page View Complete Literature Guide for MDS3
1) Benni ML and Neigeborn L  (1997) Identification of a new class of negative regulators affecting sporulation-specific gene expression in yeast. Genetics 147(3):1351-66
2) Davis DA, et al.  (2002) Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesis. Genetics 162(4):1573-81
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Zacchi LF, et al.  (2010) Mds3 Regulates Morphogenesis in Candida albicans through the TOR Pathway. Mol Cell Biol 30(14):3695-710