MDR1/YGR100W Summary Help

Standard Name MDR1 1
Systematic Name YGR100W
Alias MIC1 , GYP2
Feature Type ORF, Verified
Description Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function (2, 3, 4)
Name Description Mac1-Dependent Regulator
Chromosomal Location
ChrVII:690245 to 693097 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MDR1 GO evidence and references
  View Computational GO annotations for MDR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Large-scale survey
null
overexpression
Resources
45 total interaction(s) for 39 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 6
  • Co-purification: 1

Genetic Interactions
  • Dosage Lethality: 3
  • Negative Genetic: 19
  • Positive Genetic: 1
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 950
Molecular Weight (Da) 109,258
Isoelectric Point (pI) 5.14
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:690245 to 693097 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2853 690245..693097 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003332
References cited on this page View Complete Literature Guide for MDR1
1) Serpe, M. and D.J. Kosman  (1996) MDR1 encodes a protein interacting with Mac1p, a nuclear metal activator. Unpublished
2) Albert S and Gallwitz D  (1999) Two new members of a family of Ypt/Rab GTPase activating proteins. Promiscuity of substrate recognition. J Biol Chem 274(47):33186-9
3) Lafourcade C, et al.  (2003) Opposite roles of the F-box protein Rcy1p and the GTPase-activating protein Gyp2p during recycling of internalized proteins in yeast. Genetics 164(2):469-77
4) Sciorra VA, et al.  (2005) Synthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway. Mol Biol Cell 16(2):776-93