Standard Name	MDM38
Systematic Name	YOL027C
Alias	MKH1 1
Feature Type	ORF, Verified
Description	Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome (1, 2, 3, 4, 5)
Name Description	Mitochondrial Distribution and Morphology 2

Chromosomal Location	ChrXV:273724 to 272003 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for MDM38
Molecular Function
Manually curated	ribosome binding (IDA)
Biological Process
Manually curated	cellular potassium ion homeostasis (IMP) mitochondrial respiratory chain complex III biogenesis (IGI, IMP) mitochondrial respiratory chain complex IV biogenesis (IGI, IMP) positive regulation of mitochondrial translation (IGI) potassium ion transport (IGI, IMP) protein insertion into mitochondrial membrane (IMP) proton transport (IGI)
Cellular Component
Manually curated	mitochondrial inner membrane (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	mitochondrial morphology: abnormal respiratory Complex IV accumulation: decreased respiratory Complex III accumulation: decreased respiratory growth: absent viable
Large-scale survey
null	acid pH resistance: decreased glutathione excretion: increased chitin deposition: increased competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased mitochondrial morphology: abnormal resistance to CTBT: decreased resistance to nickel(2+): decreased resistance to elesclomol-Cu: decreased respiratory growth: absent respiratory growth: decreased rate utilization of carbon source: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	181 total interaction(s) for 154 unique genes/features.
Physical Interactions	Affinity Capture-MS: 54 Affinity Capture-Western: 5 Co-fractionation: 8
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 4 Negative Genetic: 85 Positive Genetic: 14 Synthetic Growth Defect: 6 Synthetic Lethality: 2 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:273724 to 272003 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1722 273724..272003 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005387