MDM36/YPR083W Summary Help

Standard Name MDM36 1
Systematic Name YPR083W
Feature Type ORF, Verified
Description Mitochondrial protein; required for normal mitochondrial morphology and inheritance; component of the mitochondria-ER-cortex-ancor (MECA); interacts with Num1p to link the ER and mitochondria at the cell cortex; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission (1, 2, 3)
Name Description Mitochondrial Distribution and Morphology 1
Chromosomal Location
ChrXVI:704854 to 706593 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MDM36 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
38 total interaction(s) for 37 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 4
  • Co-purification: 1
  • Protein-RNA: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 5

Genetic Interactions
  • Negative Genetic: 19
  • Phenotypic Suppression: 2
  • Positive Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 579
Molecular Weight (Da) 64,958
Isoelectric Point (pI) 5.22
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:704854 to 706593 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1740 704854..706593 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006287
References cited on this page View Complete Literature Guide for MDM36
1) Dimmer KS, et al.  (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
2) Hammermeister M, et al.  (2010) Mdm36 Is a Mitochondrial Fission-promoting Protein in Saccharomyces cerevisiae. Mol Biol Cell 21(14):2443-52
3) Lackner LL, et al.  (2013) Endoplasmic reticulum-associated mitochondria-cortex tether functions in the distribution and inheritance of mitochondria. Proc Natl Acad Sci U S A 110(6):E458-67