MDM20/YOL076W Summary Help

Standard Name MDM20
Systematic Name YOL076W
Alias DEC1 , NAA25 1
Feature Type ORF, Verified
Description Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly (2, 3)
Name Description Mitochondrial Distribution and Morphology
Chromosomal Location
ChrXV:187024 to 189414 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MDM20 GO evidence and references
  View Computational GO annotations for MDM20
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
58 total interaction(s) for 45 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-Western: 1
  • Co-fractionation: 2

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 3
  • Phenotypic Enhancement: 2
  • Synthetic Growth Defect: 20
  • Synthetic Lethality: 13
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 796
Molecular Weight (Da) 92,808
Isoelectric Point (pI) 7.7
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:187024 to 189414 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2391 187024..189414 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005436
References cited on this page View Complete Literature Guide for MDM20
1) Polevoda B, et al.  (2009) A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. BMC Proc 3 Suppl 6:S2
2) Singer JM and Shaw JM  (2003) Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast. Proc Natl Acad Sci U S A 100(13):7644-9
3) Polevoda B, et al.  (2003) Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin. J Biol Chem 278(33):30686-97