MDM20/YOL076W Summary Help

Standard Name MDM20 1
Systematic Name YOL076W
Alias DEC1 , NAA25 2
Feature Type ORF, Verified
Description Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly (3, 4)
Name Description Mitochondrial Distribution and Morphology 5
Chromosomal Location
ChrXV:187024 to 189414 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MDM20 GO evidence and references
  View Computational GO annotations for MDM20
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
58 total interaction(s) for 45 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-Western: 1
  • Co-fractionation: 2

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 3
  • Phenotypic Enhancement: 2
  • Synthetic Growth Defect: 20
  • Synthetic Lethality: 13
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 796
Molecular Weight (Da) 92,808
Isoelectric Point (pI) 7.7
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:187024 to 189414 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2391 187024..189414 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005436
References cited on this page View Complete Literature Guide for MDM20
1) Hermann GJ, et al.  (1997) The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton. J Cell Biol 137(1):141-53
2) Polevoda B, et al.  (2009) A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. BMC Proc 3 Suppl 6:S2
3) Singer JM and Shaw JM  (2003) Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast. Proc Natl Acad Sci U S A 100(13):7644-9
4) Polevoda B, et al.  (2003) Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin. J Biol Chem 278(33):30686-97
5) Sogo LF and Yaffe MP  (1994) Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. J Cell Biol 126(6):1361-73