MDM12/YOL009C Summary Help

Standard Name MDM12 1
Systematic Name YOL009C
Feature Type ORF, Verified
Description Mitochondrial outer membrane protein, ERMES complex subunit; required for transmission of mitochondria to daughter cells; required for mitophagy; may influence import and assembly of outer membrane beta-barrel proteins; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase (1, 2, 3, 4, 5, 6)
Name Description Mitochondrial Distribution and Morphology 1
Chromosomal Location
ChrXV:310139 to 309324 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All MDM12 GO evidence and references
  View Computational GO annotations for MDM12
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
Large-scale survey
225 total interaction(s) for 188 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 15
  • PCA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 146
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 10
  • Synthetic Growth Defect: 26
  • Synthetic Lethality: 12
  • Synthetic Rescue: 2

Expression Summary
Length (a.a.) 271
Molecular Weight (Da) 30,728
Isoelectric Point (pI) 4.15
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXV:310139 to 309324 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..816 310139..309324 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005369
References cited on this page View Complete Literature Guide for MDM12
1) Berger KH, et al.  (1997) Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast. J Cell Biol 136(3):545-53
2) Boldogh IR, et al.  (2003) A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery. Mol Biol Cell 14(11):4618-27
3) Meisinger C, et al.  (2007) The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J 26(9):2229-39
4) Kornmann B, et al.  (2009) An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 325(5939):477-81
5) Bockler S and Westermann B  (2014) Mitochondrial ER Contacts Are Crucial for Mitophagy in Yeast. Dev Cell 28(4):450-8
6) Cohen Y, et al.  (2014) Peroxisomes are juxtaposed to strategic sites on mitochondria. Mol Biosyst 10(7):1742-8