MDM10/YAL010C Summary Help

Standard Name MDM10
Systematic Name YAL010C
Alias FUN37 1
Feature Type ORF, Verified
Description Subunit of both the ERMES and the SAM complex; component of ERMES complex which acts as a molecular tether between the mitochondria and the ER, necessary for efficient phospholipid exchange between organelles and for mitophagy; SAM/TOB complex component that functions in the assembly of outer membrane beta-barrel proteins; involved in mitochondrial inheritance and morphology; ERMES complex is often co-localized with peroxisomes and concentrated areas of pyruvate dehydrogenase (2, 3, 4, 5, 6, 7)
Name Description Mitochondrial Distribution and Morphology
Chromosomal Location
ChrI:135665 to 134184 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MDM10 GO evidence and references
  View Computational GO annotations for MDM10
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
conditional
null
overexpression
Large-scale survey
null
Resources
290 total interaction(s) for 190 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 31
  • PCA: 1

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 3
  • Negative Genetic: 176
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 2
  • Positive Genetic: 33
  • Synthetic Growth Defect: 24
  • Synthetic Lethality: 5
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 493
Molecular Weight (Da) 56,237
Isoelectric Point (pI) 7.34
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:135665 to 134184 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1482 135665..134184 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000008
References cited on this page View Complete Literature Guide for MDM10
1) Clark MW, et al.  (1994) Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region. Yeast 10(4):535-41
2) Meisinger C, et al.  (2004) The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev Cell 7(1):61-71
3) Meisinger C, et al.  (2007) The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J 26(9):2229-39
4) Kornmann B, et al.  (2009) An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 325(5939):477-81
5) Tan T, et al.  (2013) Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis. J Cell Sci 126(Pt 16):3563-74
6) Bockler S and Westermann B  (2014) Mitochondrial ER Contacts Are Crucial for Mitophagy in Yeast. Dev Cell 28(4):450-8
7) Cohen Y, et al.  (2014) Peroxisomes are juxtaposed to strategic sites on mitochondria. Mol Biosyst 10(7):1742-8