MDL2/YPL270W Summary 
| Standard Name | MDL2 (see Nomenclature conflict Note) |
|---|---|
| Systematic Name | YPL270W |
| Feature Type | ORF, Verified |
| Description | Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis (1, 2 and see Summary Paragraph) |
| Name Description | MultiDrug resistance-Like 1 |
| Chromosomal Location | |
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| View Computational GO annotations for MDL2 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated | |
| High-throughput |
| 91 total interaction(s) for 71 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
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| Last Update | Coordinates: 2003-09-22 | Sequence: 2003-09-22 | ||||||||||||
| Subfeature details |
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| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB |
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| Primary SGDID | S000006191 |
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NOMENCLATURE CONFLICT NOTE
| Name | Relevance | Description |
|---|---|---|
| SSH1 | Nomenclature conflict | SSH1 has been used to refer to both MDL2/YPL270W, which encodes a mitochondrial inner membrane transporter, and SSH1/YBR283C, which encodes a protein involved in co-translational protein targeting to the endoplasmic reticulum. |
MDL1 and MDL2 encode members of the ATP-binding Cassette (ABC) transporter family that reside in the mitochondrial inner membrane (1, 2). They are classified as "half-molecule" family members because they are comprised of one transmembrane domain and one nucleotide-binding domain, in contrast to "full-size" family members in which this arrangement is repeated in tandem. Mdl1p and Mdl2p are similar to each other and to other ABC family members, in particular to human TAP1 and TAP2, which form a heterodimer that transports peptides from the cytoplasm into the endoplasmic reticulum (1). Defects in TAP1 and TAP2 are linked to bare lymphocyte syndrome (OMIM) and Wegener-like granulomatosis (OMIM).
Although Mdl2p is very similar to Mdl1p, which exports peptides from mitochondria, the mdl2 null mutation does not affect peptide export. In contrast to mdl1, the mdl null mutation prevents respiratory growth at high temperature (2). Large-scale studies have also detected osmotic stress resistance and oleate sensitivity phenotypes of the mdl2 null mutant (3, 4).
Last updated: 2010-02-09 
| 1) | Dean M, et al. (1994) Mapping and sequencing of two yeast genes belonging to the ATP-binding cassette superfamily. Yeast 10(3):377-83 |
| 2) | Young L, et al. (2001) Role of the ABC transporter Mdl1 in peptide export from mitochondria. Science 291(5511):2135-8 |
| 3) | Yoshikawa K, et al. (2009) Comprehensive phenotypic analysis for identification of genes affecting growth under ethanol stress in Saccharomyces cerevisiae. FEMS Yeast Res 9(1):32-44 |
| 4) | Lockshon D, et al. (2007) The sensitivity of yeast mutants to oleic Acid implicates the peroxisome and other processes in membrane function. Genetics 175(1):77-91 |
