MCP2/YLR253W Summary Help

Standard Name MCP2 1
Systematic Name YLR253W
Feature Type ORF, Verified
Description Mitochondrial protein of unknown function involved in lipid homeostasis; integral membrane protein that localizes to the mitochondrial inner membrane; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10, and other members of the ERMES complex; transcription is periodic during the metabolic cycle; homologous to human aarF domain containing kinase, ADCK1 (1, 2, 3, 4, 5)
Name Description Mdm10 Complementing Protein 1
Chromosomal Location
ChrXII:642627 to 644336 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MCP2 GO evidence and references
  View Computational GO annotations for MCP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Classical genetics
overexpression
Large-scale survey
null
overexpression
Resources
33 total interaction(s) for 27 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 2

Genetic Interactions
  • Negative Genetic: 18
  • Positive Genetic: 10
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 569
Molecular Weight (Da) 65,917
Isoelectric Point (pI) 9.45
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:642627 to 644336 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1710 642627..644336 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004243
References cited on this page View Complete Literature Guide for MCP2
1) Tan T, et al.  (2013) Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis. J Cell Sci 126(Pt 16):3563-74
2) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Tu BP, et al.  (2005) Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes. Science 310(5751):1152-8
5) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54