MCM16/YPR046W Summary Help

Standard Name MCM16 1
Systematic Name YPR046W
Feature Type ORF, Verified
Description Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 (1, 2, 3)
Name Description MiniChromosome Maintenance 4
Chromosomal Location
ChrXVI:656799 to 657344 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MCM16 GO evidence and references
  View Computational GO annotations for MCM16
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 81 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
222 total interaction(s) for 123 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 43
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 6
  • Co-crystal Structure: 1
  • Two-hybrid: 40

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 4
  • Negative Genetic: 62
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 7
  • Synthetic Growth Defect: 35
  • Synthetic Lethality: 18
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 181
Molecular Weight (Da) 21,138
Isoelectric Point (pI) 5.67
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:656799 to 657344 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..546 656799..657344 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006250
References cited on this page View Complete Literature Guide for MCM16
1) Sanyal K, et al.  (1998) The MCM16 gene of the yeast Saccharomyces cerevisiae is required for chromosome segregation. Mol Gen Genet 260(2-3):242-50
2) Measday V, et al.  (2002) Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore. Genes Dev 16(1):101-13
3) Schleiffer A, et al.  (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13
4) Maine GT, et al.  (1984) Mutants of S. cerevisiae defective in the maintenance of minichromosomes. Genetics 106(3):365-85