MCM1/YMR043W Summary Help

MCM1 BASIC INFORMATION

Standard Name MCM1 1, 2, 3
Systematic Name YMR043W
Alias FUN80 4
Feature Type ORF, Verified
Description Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes (5, 6, 7)
Name Description MiniChromosome Maintenance 8
GO Annotations All MCM1 GO evidence and references
    View Computational GO annotations for MCM1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Binding motifs MCM1 Transcription Factor Binding Sites and References
  • CCNRATNNGG
  • WTWCCYAAWNNGGTAA
Regulatory modules predicted: stressResponse ( 403 , 385 , 379 )
Mutant Phenotype All MCM1 Phenotype details and references
Classical genetics
overexpression
reduction of function
Large-scale survey
conditional
null
Interactions MCM1 All interactions details and references
44 total interaction(s) for 25 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-Western: 7
  • Co-crystal Structure: 2
  • Reconstituted Complex: 12
  • Two-hybrid: 11
Genetic Interactions
  • Dosage Rescue: 6
  • Synthetic Rescue: 2
Sequence Information
ChrXIII:353870 to 354730 | ORF Map | GBrowse
Gbrowse
Genetic position: 35 cM
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..861 353870..354730 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004646

MCM1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for MCM1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MCM1]

1) Maine, G.T.  (1984) Ph.D. thesis Personal Communication
2) Maine, G. and Tye, B.  (1985) Personal Communication, Mortimer Map Edition 9
3) Elble, R., et al.  (1989) ; Personal Communication, Mortimer Map Edition 10
4) Dubois E, et al.  (1987) Characterization of two new genes essential for vegetative growth in Saccharomyces cerevisiae: nucleotide sequence determination and chromosome mapping. Gene 55(2-3):265-75
5) Passmore S, et al.  (1989) A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes. Genes Dev 3(7):921-35
6) Elble R and Tye BK  (1991) Both activation and repression of a-mating-type-specific genes in yeast require transcription factor Mcm1. Proc Natl Acad Sci U S A 88(23):10966-70
7) Lydall D, et al.  (1991) A new role for MCM1 in yeast: cell cycle regulation of SW15 transcription. Genes Dev 5(12B):2405-19
8) Maine GT, et al.  (1984) Mutants of S. cerevisiae defective in the maintenance of minichromosomes. Genetics 106(3):365-85